Splenomegaly
Splenomegaly is an enlargement of the spleen, which usually lies in
the left upper quadrant (LUQ) of the human abdomen. It is one of the
cardinal signs of hypersplenism. Splenomegaly is usually associated with
increased workload (such as in hemolytic anemias), which suggests that
it is a response to hyperfunction. It is therefore not surprising that
splenomegaly is associated with any disease process that involves
abnormal red blood cells being destroyed in the spleen.
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